How Can One Tell Which Identical Twin May Have Committed A Crime? ==
April 27th 2010 13:26
== Identifying Identical Twins' DNA...How Can One Tell Which Identical Twin May Have Committed A Crime? ==
:[[Identical twins]] have the same genetic material, as the article explains.
:How about good old fashioned [[fingerprint]]s? You might get lucky and find a SNP ([[Single nucleotide polymorphism]]) that is different between the twins but [[DNA fingerprinting]] would be useless with the current genetic markers
::They come from the same egg and sperm so there will not be SNPs between them. Now let me qualify that by saying that if spontanious mutation did arise during the development of one of them, it would not be in all their cells, only the cells that are descendant of that cell. You cannot tell them apart by genetic means. How can you tell which one committed a crime? It could be very tricky indeed. Even with other evidence like alibis, a defense lawyer could definately put together a case where you couldn't tell which twin was which. Tattoos, scars etc would be very useful. I'm sure there are some interesting case studies out there... Another interesting point - total bone marrow transplants (eg. for leukaemia) mean that the patient's blood has the same DNA as the donor. But there would likely be other markers in the blood - antirejection drugs maybe? [[User:Aaadddaaammm|Aaadddaaammm]] 22:58, 18 May 2007 (UTC)
:::"Somatic mosaicism" for SNP's is not uncommon but finding one that occured early enough in development would be very difficult (if not impossible). Hence my disclaimer, you might get lucky. The important observation is that it is wrong to assume that identical twins have identical DNA.
:
ome genes undergo [[somatic hypermutation]] and [[V(D)J recombination|other types of modifications]] that make the DNA sequences in some somatic cells of each individual unique. Also, DNA modifications such as [[DNA methylation]] can be different between [[monozygotic twins==
:[[Identical twins]] have the same genetic material, as the article explains.
:How about good old fashioned [[fingerprint]]s? You might get lucky and find a SNP ([[Single nucleotide polymorphism]]) that is different between the twins but [[DNA fingerprinting]] would be useless with the current genetic markers
::They come from the same egg and sperm so there will not be SNPs between them. Now let me qualify that by saying that if spontanious mutation did arise during the development of one of them, it would not be in all their cells, only the cells that are descendant of that cell. You cannot tell them apart by genetic means. How can you tell which one committed a crime? It could be very tricky indeed. Even with other evidence like alibis, a defense lawyer could definately put together a case where you couldn't tell which twin was which. Tattoos, scars etc would be very useful. I'm sure there are some interesting case studies out there... Another interesting point - total bone marrow transplants (eg. for leukaemia) mean that the patient's blood has the same DNA as the donor. But there would likely be other markers in the blood - antirejection drugs maybe? [[User:Aaadddaaammm|Aaadddaaammm]] 22:58, 18 May 2007 (UTC)
:::"Somatic mosaicism" for SNP's is not uncommon but finding one that occured early enough in development would be very difficult (if not impossible). Hence my disclaimer, you might get lucky. The important observation is that it is wrong to assume that identical twins have identical DNA.
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